The endothelial glycocalyx is a gel like substance that lines the microcapillaries. It seems that when this is damaged or exposed to inflammation it triggers much of the degradation we see in capillary function with aging.

Structure of endothelial glycocalyx and its activation of vascular muscle relaxation via nitric oxide (NO) in response to increased shear force.

The endothelial glycocalyx:

• Regulates vascular permeability and fluid balance due to the large size and negative charge of its glycosaminoglycans.
• Provides a physical barrier against inadvertent adhesion of platelets and leukocytes to the vascular wall.
• Regulates coagulation as many of mediators of coagulation pathway are buried inside the glycocalyx under normal physiological condition.
• Functions as a mechano-sensor and transducer of the shear-force inside blood vessels to regulate the synthesis of nitric oxide (NO) in response to the blood flow

Sulfated polysaccharides from seaweed have been found to be able to prevent and repair the damage to the endothelial glycocalyx.

These polysaccharides are available in supplement form in a product called Arterosil. Arterosil is a proprietary blend of compounds that can not only improve EGC function and arterial flexibility, but also reduce blood pressure, prevent endothelial inflammation, and slow or even reverse existing plaque build up on arterial walls.

Glycocalyx Damage and Associated Pathologies

The endothelial glycocalyx is a delicate structure and can be damaged under many conditions. The primary contributors to breakdown of the endothelial glycocalyx are high blood glucose, oxidative stress and inflammation. Pathologies associated with impaired endothelial glycocalyx include:

• Coronary heart disease
• Hyperglycemia
• Diabetes
• Renal diseases
• Lacunar stroke
• Severe trauma

If you want more info on the supplement including research studies refer to https://arterosil.com/

Heres a similar supplement made from a different seaweed https://microvascular.com/endocalyx-anti-aging-supplement/

If you want proof of microcirculatory function in the form of medical testing refer to https://glycocheck.com/

PS: Dont worry folks I will dig to the bottom of this & find a cheap bulk supplier for effective seaweed supplementation

PPS: Fucoidan (brown seaweed extract) does the job. Available in bulk on aliexpress. Also many brands on Ebay & Amazon. hyaluronan also helps.

Comments are closed.