Posts Tagged ‘resveratrol’

The following supplements have scientifically proven benefits for extending lifespan:

IGF-1 found in colostrum and deer antler. The affect of IGF on elderly and seniors in pronounced. Greater strength and musculature, better connective tissue and general youthfulness.

DHEA and 7-KETO again these are of great benefit to seniors enhancing androgenic profile found in small amounts in pine pollen.

Pterostilbene & Resveratrol. You most probably have heard of resveratrol, pterostilbene is a super derivative that activates more mitochondrial factors. If you want more mitochondria that work much better take both.

NAD+ is a derivative of niacin vitamin B3.

— Promote Sirtuin Gene Activation (using SIRT1 and SIRT3)

— Enhance The Growth And Efficiency Of Mitochondria, Which Boosts Physical And Mental Energy Throughout The Body

— Optimize Metabolism

— Enhance Cognitive Health And Reverse The Effects Of Aging On The Brain

— Promote Insulin Sensitivity And Encourage Healthy Blood Sugar Levels

— Repair DNA

OK so these represent a good basic anti aging regimen with an emphasis on mitochondria and hormonal profile. There are of course 50-100 supplements you can take to enhance anti aging and brain function.

When you eat food you get a full range of nutrients just in too small of a quantity for any pharmacological effect.

When taking supplements expect the same. A larger range of carefully chosen supplements will be better than just a few.

Spermadine & resveratrol are autophagic – meaning they assist the cell to clean out waste tissue and cellular damage. This promotes longevity of the cells.

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that autophagy is also involved in pharmacological manipulations that increase longevity. According to the study by the INSERM, exogenous supply of the polyamine spermidine can prolong the lifespan of (while inducing autophagy in) yeast, nematodes and flies. Similarly, resveratrol can trigger autophagy in cells from different organisms, extend lifespan in nematodes, and ameliorate the fitness of human cells undergoing metabolic stress. These beneficial effects are lost when essential autophagy modulators are genetically or pharmacologically inactivated, indicating that autophagy is required for the cytoprotective and/or anti-aging effects of spermidine and resveratrol. Genetic and functional studies indicate that spermidine inhibits histone acetylases, while resveratrol activates the histone deacetylase Sirtuin 1 to confer cytoprotection/longevity. Although it remains elusive whether the same histones (or perhaps other nuclear or cytoplasmic proteins) act as the downstream targets of spermidine and resveratrol, these results point to an essential role of protein hypoacetylation in autophagy control and in the regulation of longevity

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.

Spermadine is found in grapefruit & resveratrol in red grape.